Similarly, for kidney health, the FLOW trial demonstrated that semaglutide reduced the risk of severe kidney outcomes, including kidney failure and death, by 24% (HR 0.76, 95% CI 0.660.88)
ARRESTS and EXE
A 2025 study published in AJMC found that many patients who stopped semaglutide or tirzepatide in real-world settings did not regain weight as rapidly as clinical trial outcomes suggested, particularly when tapering was gradual, and lifestyle support was in place
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