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Hyaluronic acid (HA), one of the key components of the extracellular matrix, has been used frequently as a polysaccharide-targeting moiety, which can selectively recognized by the endogenous lectins, like two hyaluronic acid receptors, called cluster determinant 44 (CD44) and receptor for hyaluronan-mediated motility (RHAMM), highly expressed on the plasma membrane of cancer cells [219, 220]

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