In a post-hoc analysis of the published SURPASS trials, the change in systolic blood pressure was greater for tirzepatide versus the comparators of the trials (tirzepatide 5 mg: -5.1 to -1.3 mmHg, tirzepatide 10 mg: -6.5 to -1.7 mmHg, tirzepatide 15 mg: -11.5 to -3.1 mmHg) [65]
We should use appropriate caution when interpreting these results
Results from these trials will be critical in determining if GLP1s could become part of a future dementia treatment strategy
Insulin levels start returning to pre-medication levels relatively quickly
Clinical trials involving Mounjaro have shown that people can lose an average 22.5% of their starting body weight by reaching the maximum maintenance dose of 15mg per week after 72 weeks
*Correspondence: Zhonglan Wu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers