This type of GLP-1 agonists provides extended glycemic control and cardiovascular benefits
Protocol 2: experienced (already on stable semaglutide dose) If you are already on a stable semaglutide dose and want to add creatine: Week 1: Start with 3 grams creatine monohydrate daily, taken with your post-workout meal (or largest meal on non-training days)
Renal outcomes in the EXenatide study of cardiovascular event lowering (EXSCEL)
Iorga RA, Bacalbasa N, Carsote M, Bratu OG, Stanescu AMA, Bungau S, Pantis C, Diaconu CC (2020) Metabolic and cardiovascular benefits of GLP-1 agonists, besides the hypoglycemic effect (Review)
Over weeks and months, this adds up to significant muscle loss that is extremely difficult to reverse
For example, some studies reported an average weight loss of 5.4% to 8.1% of starting body weight with Contrave, versus 1.3% to 4.9% with placebo