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The IGF-1R promoter is targeted by several oncogenes

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It is documented in hypothyroid patients treated with levothyroxine (LT4) [14], in menopause [7], central disorders of hypersomnolence (such as narcolepsy and idiopathic hypersomnia), multiple sclerosis, lupus erythematosus [15], depression [16], and celiac disease [18]

Esta diferencia farmacolgica puede influir en la eficacia y en el perfil de efectos adversos