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It also disrupts T cell proliferation, activation, and effector cytokine expression by specifically depleting the extracellular space of glutamine through the inhibition of cMyc and IRF4 expression (Wstner et al., 2015)

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TNF- inhibitors not only improve inflammation-associated bone metabolic disorders but also show therapeutic potential in inflammatory bone loss diseases such as RA, inflammatory bowel disease (IBD), and ankylosing spondylitis (AS) (90, 91)

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when used incorrectly, they might lead to irritation

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