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The most common side effects include gastrointestinal issues such as stomach pain or abdominal pain, diarrhea, nausea, constipation, and vomiting
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These gastrointestinal effects are typically most pronounced during the first few weeks at each dose level and tend to improve as the body adjusts
Details regarding the inclusion and exclusion criteria are provided in the Supplementary Appendix (available at NEJM.org)
Reconstitution supplies Bacteriostatic water (approximately $5 to $10 per 30ml vial, needing 2 to 4 vials total), alcohol prep pads ($5 to $10 per box of 100), and insulin syringes ($15 to $25 per box of 100)
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