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(LCA) lithocolic acid , (INT-777) semisynthetic bile acid, (GSIS) Glucose-stimulated insulin secretion
Does not address the broader transit slowdown caused by GLP-1 medications
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It does not work through appetite suppression, so eating behavior remains normal
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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)
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