Measured Wound Fluid Concentrations: In human wound fluid collected after abdominal surgery, T4 reached concentrations up to 20 mg/L immediately post-surgery, declining to approximately 1 mg/L within 60 hours (PMID 17495244)
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In research models, this inhibition indirectly preserves NAD by reducing methylation of nicotinamide, and also maintains SAM levels an effect precursors do not address
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