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[PMID: 23808802] PubMed record related to this compound for laboratory literature review
In animals, Wu et al
Referenced a specific detail from the conversation (abstraction backlog)
Typical amino acids are replaced by others rendering the enzyme defective or inactive MTHFR 677CC = a normal MTHFR gene MTHFR 677CT = a heterozygous mutation which is one mutation MTHFR 677TT = a homozygous mutation which is two mutations MTHFR 1298AA = a normal MTHFR gene MTHFR 1298AC = a heterozygous mutation which is one mutation MTHFR 1298CC = a homozygous mutation which is two mutations MTHFR 677CT + MTHFR 1298AC = a compound heterozygous mutation which is one mutation from two different parts of the gene MTHFR 677TT + MTHFR 1298CC= DOUBLE Compound Heterozygus Treatment: (of course always speak with a knowledgeable provider) May or may not include
consider using a non-oral or barrier method for 4 weeks after initiation and after each dose increase
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