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TadokoroTIkedaMIdeTDeguchiHIkedaSOkabeKet alMitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity
Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
Today 328 , 27 (2019)
Adults can completely fail to absorb the vitamin administered orally
