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Individuals with digestive conditions such as Crohns disease, celiac disease, or those whove undergone certain procedures affecting the stomach or small intestine may struggle with absorption

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When ROS levels outpace the bodys natural defense systems, it leads to lipid peroxidation, which causes premature muscle fatigue and a drop in power output

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Because of the location of the PEG moiety and absence of additional modifications at the C-terminus of the FGF21 moiety, pegbelfermin remains susceptible to FAP cleavage and inactivation