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Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia
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The sub-30-minute half-life documented in preclinical research provides a pharmacokinetic rationale for twice-daily dosing
As a result, these agents act together to cause additional oxidative damage, creating a never-ending chain reaction (also may be considered a feed-forward loop)
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