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There is an increased risk of overdosing or underdosing GLP-1 medications when switching
This mechanism is likely dose-dependent and receptor-mediated, unlike the weight-loss mechanism
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DSIPs limited data suggest potential sleep-promoting effects without significant next-day cognitive impairment, though comparative trials are lacking
GLP-1-only agonists like semaglutide often require slower titration and have a longer safety history in clinical use
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