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Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively

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Patients who have previously experienced an allergic reaction (such as anaphylaxis, angioedema, or urticaria) after MB administration should not be re-exposed

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