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Small changes in the time of administration relative to ischemia can shift PRPs effect from anti-apoptotic to apparently pro-inflammatory, as shown in models where PRP given before ischemia produced stronger protective outcomes than when applied at reperfusion 52

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doi: 10.1093/jn/135.8.2060S 91 La VigneraSCondorelliRVicariED'AgataRCalogeroAE

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