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The metal-peptide complex can dissociate at elevated temperatures, releasing free copper and reducing efficacy

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Front Cell Neurosci 11:325 Oliveira KRHM, Dos Anjos LM, Arajo APS, Luz WL, Kauffmann N, Braga DV, Passos ADCF, de Moraes SAS (2019) Ascorbic acid prevents chloroquine-induced toxicity in inner glial cells

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