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New constructs reported in this Article are available from Addgene: H2BHTemiRFP703 (183985), HTmGold (183986), calnexinHTmGold (183987), H2BHTmGold (183988) and calnexinHT8mGold (183989)

To identify potentially meaningful yet nonsignificant changes, effect sizes appropriate for nonparametric data were also calculated

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Those are a hormonal system issue , triggered by fluctuating estrogen levels messing with your hypothalamus