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The clinical data revealed that after just three months of supplementation, the high-dose Setria group experienced a remarkable two-fold (greater than 200%) increase in Natural Killer cell cytotoxicity compared to baseline

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In addition, metformin significantly inhibits angiogenesis through downregulated VEGF activity induced by the IL-6/STAT3 or AMPK/mTOR signaling pathways (Rattan et al., 2011