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Crucially, the individual component would incorporate key personal variables such as genetic polymorphisms (e.g., in Nrf2 or metabolic enzyme genes), gut microbiome composition (which metabolizes many hormetins), age, and baseline health status

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"Weight regain and cardiometabolic effects after withdrawal of semaglutide." Diabetes, Obesity and Metabolism , 24(8), 1553-1564

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10.1016/s1570-0232(03)00264-2 16 GaudianoM

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GLP-1 receptor agonists modify gut motility, which affects bacterial populations

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Diab Care 37 , 21492158 (2014)

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Linoleic acid metabolite drives severe asthma by causing airway epithelial injury

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