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These animals were also subjected to the same environmental conditions and treatment protocols for a chronic 28-day administration study [2]

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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

Tesamorelin stimulates growth hormone release and has FDA approval for HIV-associated lipodystrophy