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Diabetes 54:23902395 Wynne K, Park AJ, Small CJ et al (2006) Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial

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A recent study found that the ability of metformin to promote GLP-1 secretion was impaired in mice with a gut-specific knockout of the PEN2 gene (Ma et al., 2022)