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Fibroblasts also secrete substances, like vascular endothelial growth factor (VEGF), which promote the growth of blood vessels
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With more receptors, neurons attempt to restore the signals to normal
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When this happens, most of the discoloration seen is that of the medicine and not the occasional nick of a capillary
NICE guidelines recommend hydroxocobalamin 1 mg intramuscularly three times weekly for 2 weeks (without neurological involvement) or on alternate days until no further improvement (with neurological symptoms)
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