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Blood levels quickly rise to 560,000,000pmol/L, and if necessary, treatment is repeated within hours for a total of 10,000,000mcg of B12

B12 deficiency produces a recognizable cluster of symptoms: fatigue, weakness, neurological changes including tingling or numbness in the extremities, cognitive fog, and in more severe cases, megaloblastic anemia

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High oral bioavailability Caco-2 cell assays showed excellent passive and active membrane transport with no detectable efflux (Neelakantan et al., 2018)

Also prohibited in this category are intravenous infusions or injections that exceed 100 mL in 12 hours, except those that are part of medical treatments

The B12 component may help if low B12 is contributing, though much of this early tiredness comes from the calorie drop itself and tends to ease as your body adjusts