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The trial also identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients a safety signal that doesn't appear in the cagrilintide literature
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De Luca M, Segato G, Busetto L, Favretti F, Aigner F, Weiss H, de Gheldere C, Gaggiotti G, Himpens J, Limao J, Scheyer M, Toppino M, Zurmeyer EL, Bottani G, Penthaler H
Your provider may also consider slowing dose escalation, temporarily reducing your dose, or prescribing antiemetic medications if symptoms significantly impact your quality of life or nutritional intake
While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations
Both belong side by side methodologically and not as substitutes for each other
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