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Moving forward, the most realistic near-term translational path lies in combining relatively simple, biocompatible bone-targeted nanocarriers (such as alendronate-functionalized liposomal or polymeric systems) to specifically co-deliver immunogenic cell death (ICD)-inducing standard chemotherapeutics alongside established immune checkpoint inhibitors (e.g., anti-PD-1/PD-L1) or myeloid cell modulators

Covalent warheads targeting cysteine residue: the promising approach in drug development

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Labs are checked at baseline and 8-12 weeks to ensure IGF-1, fasting glucose, and lipids are in healthy ranges

Problems with liver enzymes Overusing glutathione can change liver enzymes or hide problems with the liver because it affects the processes that detoxify the liver

HR 0.69, 95% CI 0.560.84