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The honest answer is that the two forms are not interchangeable, and the oral route has a specific rationale that is worth understanding before you choose it

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A 2025 study published in Frontiers in Pharmacology examined GHK-Cu's effects in a colitis model, finding that it modulated SIRT1 and STAT3 signaling in colon tissue a reminder that this peptide's research footprint extends well past skin and hair into broader inflammatory and metabolic pathways

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