Localization of gene for human p53 tumour antigen to band 17p13
These subcellular alterations not only directly damage structural cells (e.g., airway epithelium) but also release damage-associated molecular patterns (DAMPs) and oxidized lipids that activate and recruit immune cells (85)
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Furthermore, phosphorylated JNK induces oxidative stress, mitochondrial membrane permeability, and dysfunction through the activation of Bax, the translocation of Bax to the mitochondria, the opening of the mitochondrial permeability transition pore, and Src-dependent inhibition of the electron transport complex
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