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Retatrutide for Obesity A Phase 2 Trial. NEJM 389:514-526 (2023)

Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease

6B) did not show any significant macrophage-mediated inflammatory response in any of the organs examined from the semaglutide-administered mice compared untreated wild-type controls (all p -values are shown in Supplementary Table S9)

Jin XK, Zhang SM, Liang JL, Zhang SK,Qin YT,Huang QX,Liu CJ,Zhang XZ

The drugs also improve kidney function, reduce the risk of fatal heart attacks, and are linked to protection against conditions like Alzheimers disease, but many people stop taking them because of common side effects such as nausea and vomiting