Schroeder EK, Keley NA, et al
Ross KC, Andrews AJ, Marion CD, Yen TJ, Bhattacharjee V
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A systematic comparison with other antidiabetic agents reveals notable differences in their influence on cancer risk across drug classes
The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 2 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles Library 2: 4 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 3: 8 M 8-oxo-dGTP, 0.5 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library
patients are still responsible for monthly copays, which can be $200 per month or more