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But a narrow focus on weight which, so often, our medical training still teaches misses the point that there's more to being well than a number on the scale

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They make sense conceptually but need clinical trials to determine safety, dosage, timing and interactions

The first evidence that eNOS uncoupling may be a pathophysiologically relevant phenomenon was provided by in vitro studies in which it was demonstrated that native low-density lipoprotein 81 and even more pronounced oxidized low-density lipoprotein 82 are able to stimulate endothelial superoxide production and that this phenomenon is inhibited by the NOS inhibitor N G -nitro-L-arginine methyl ester, pointing to a causal role for eNOS in superoxide production

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