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Prospective, controlled studies are needed to clarify whether GLP-1RAs have a direct therapeutic role in HS or act primarily through effects on weight and metabolic inflammation

This pricing dynamic constrains overall market penetration and slows adoption despite the strong clinical benefits of GLP-1 therapies in weight management and glycemic control, making cost a key obstacle to broader global uptake

Rapid weight loss exceeding 3-4 pounds per week sustained over multiple weeks

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Case presentation A 53-year-old man presented to our institution in 2009 with a 24-month history of difficulty in urinating and a 6-year history of melanin pigmentation of the glans penis

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