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While inhibition of COX-1 can have serious gastrointestinal consequences, selective inhibition of COX-2 carries cardiovascular risks

DOI: 10.3390/cells9071730 28

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On the other hand, prebiotics, designed substrates, were usually fructans directly entering the colon to stimulate microflora to show positive effects [73]

However, the relative abundance of the genus Parasutterella , commonly decreased by HFD 61 , was increased in both the 5A-1MQ- and vehicle-treated mice switched from WD to LD, and the abundance of Parasutterella in all mice exhibited several correlations the EWAT metabolome

they should not be taken as evidence of equivalent efficacy