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doi:10.1038/s41591-024-03015-5
Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering
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Once they came up with some promising candidates, they encountered another obstacle, which is the difficulty of getting peptides to enter cells
Simeons used around 125 IU during his studies
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