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All groups received intraperitoneal treatment injections, either DMSO (10%) or sertraline (15 mg/kg) diluted in PBS up to a volume of 500 l

Influence of recent intake: Recent B12-rich meals or injections can temporarily raise serum levels, potentially masking a deficiency

Preclinical data further indicate that liraglutide activates the SIRT1 signaling cascade, suppresses atrophy-related genes, and upregulates myogenic differentiation factors, thereby protecting against obesity-induced muscle atrophy and contributing to structural muscle integrity [14, 16]

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Strengths of this study include a large sample size from various payers