The SUSTAIN 6 trial demonstrated that semaglutide reduced major adverse cardiovascular events (a composite of cardiovascular death, nonfatal heart attack, and nonfatal stroke) by 26% in patients with type 2 diabetes and established cardiovascular disease
Who May Need Extra Caution Extra caution may be needed for patients who are pregnant or trying to become pregnant, have active cancer or a cancer history requiring specialist input, have autoimmune disease, have clotting concerns, use immune-modifying medication, have uncontrolled diabetes, have significant kidney or liver disease, or are scheduled for surgery
However, the practice lacks sufficient scientific backing and is fraught with risks, including reduced efficacy, unforeseen side effects, and the possibility of drug contamination or misuse
The only available oral GLP-1 medication is semaglutide (Rybelsus), which is FDA-approved for type 2 diabetes but not weight loss
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