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10.1016/j.virusres.2015.05.015 152 LiL.LiZ.LiX.WangE.LangF.XiaY.et al

This engagement appears to promote conformational changes in GHS-R1a, triggering G-protein activation, primarily through the Gq/11 subunit

The mechanism proposed involves chromatin remodeling at the hTERT promoter specifically, a reduction in the repressive histone modifications (H3K9me3, H3K27me3) that maintain transcriptional silencing in somatic cells allowing activating transcription factors to access promoter binding sites and initiate hTERT transcription

( Epub 2018/02/24 )

Common side effects include pain, redness, or swelling at the injection site, which typically resolve within 2448 hours

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