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Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB

doi:10.1016/j.bmcl.2018.07.009

Mechanistically, these changes appear to coincide with elevated NAD+ and activation of metabolic gene programs consistent with increased energy expenditure

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Current studies mainly focus on combinations with dietary control, exercise, and other weightloss agents, aiming to enhance efficacy and reduce side effects