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Which means the core tenet of most modern-day ancestral diets is pretty straightforward: Stick to whole, organic, seasonal, and minimally processed foods

The influence of dietary whey protein on tissue glutathione and the diseases of aging

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Female 5xFAD mice that express human APOE4 (E4FAD) exhibit increased anxiety-like behavior relative to E3FAD, and ovariectomy (OVX) in E3FAD mice increases anxiety to a similar level to intact and OVXed E4FAD mice, suggesting a protective role of ovarian hormones against anxiety-like phenotypes in E3FAD but not E4FAD mice (Taxier et al., 2022)

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Therefore, improving obesity by improving oxidative stress caused by ferroptosis in the hypothalamus and nervous system is an essential consideration