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Causes of deficiency include: Insufficient intake Malabsorption in gastrointestinal diseases Increased requirements during pregnancy Antiepileptic drugs (phenytoin, primidone, phenobarbital) may decrease FA absorption, presumably by inhibiting the formation of monoglutamine- folic acid Inhibition of dihydro-folic acid reductase (e.g., by methotrexate) depresses the formation of the active species, tetrahydro-folic acid Symptoms of deficiency are: megaloblastic anemia mucosal damage Therapy of folic acid deficiency Therapy consists in oral administration of Folic Acid or folinic acid when deficiency is caused by inhibitors of dihydroFAreductase

It also plays a role in glutathione synthesis, which supports detoxification pathways

Regimen: Initial loading injections (e.g

Can retatrutide be combined with other compounds

3, 15 Mar

Medically reviewed by Faisal Shafiq (Superintendent Pharmacist, GPhC registration number 2067224)