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Dehydration from persistent diarrhea or vomiting can lead to acute kidney injury, particularly in patients with pre-existing kidney disease or those taking medications that affect kidney function

Kalscheuer R, Stveken T, Malkus U, Reichelt R, Golyshin PN, Sabirova JS, Ferrer M, Timmis KN, Steinbchel A

These patients exhibit a greater GH secretory capacity than normal subjects, probably caused by a diminished tone in the IGF-1 sustained negative feedback control exerted upon somatotroph responsiveness

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Direct answer: In most routine cases, yes

This mechanism may contribute to both cardiovascular effects through vasomotor tone regulation and neuroprotective effects in central nervous system injury models