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[26] In 2015, the US Food and Drug Administration (FDA) added a new warning and precaution about the risk of "severe and disabling" joint pain to the labels of all DPP-4 inhibitor medicines

Omega-3 fatty acids have become less common in the standard American diet due to increased use of vegetable oils and declining pastured livestock

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For anyone taking diabetes medications, please have a discussion with your prescribing clinician prior to taking topiramate as your diabetes medications may need to be adjusted as you lose weight

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However, the formulary status (preferred or non-preferred) varies by employer and plan design