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The presence of such a gap suggested communication via chemical messengers traversing the synaptic cleft, and in 1921 German pharmacologist Otto Loewi confirmed that neurons can communicate by releasing chemicals
It can often be managed with dosage adjustments or anti-nausea medications
doi: 10.3390/ijms20143435 30 HelmstdterJFrenisKFilippouKGrillADibMKalinovicSet al
Neurons, astrocytes, oligodendrocytes, microglia, endothelial cells, and pericytes all express GLP-1 receptors, positioning incretin signaling to influence neuronal metabolism, synaptic support, neuroinflammation, myelination, vascular integrity, and bloodbrain barrier function [22]
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