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Metalloproteinase regulation studies document MMP1 and MMP2 gene expression increases at 0.01 nM with TIMP1 increases at all tested concentrations (0.01-100 nM)
Summary Keywords bioavailability, ellagic acid, ellagitannins, pharmacokinetics, polyphenols, punicalagin, TMA Citation Haarhuis JE, Ahn-Jarvis J, Savva GM, Day-Walsh PE, Ferns C, Hughes S, Triller S, Al-Jaibaji O, Philo M, Acaroz E, Perez-Moral N and Kroon PA (2026) Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults
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It is structurally classified as both a spiroindoline and spiropiperidine, and it works similarly to a peptide-based GHS called growth hormone-releasing peptide-6 (GHRP-6) [6]
Notably, the highest dose tested (54 mg) showed increased gastrointestinal event frequency compared to lower doses, suggesting a dose-relationship for this effect category
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