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For Canadians who lead active lifestyles, this extended recovery period can feel particularly challenging

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A critical period for experience-dependent remodeling of adult-born neuron connectivity

Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data

Weight reduction was assessed after 72 weeks of treatment (at least 52 weeks at maintenance dose)