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Outside clinical trials, medication effectiveness often declines because of cost, adherence issues, side effects, discontinuation, and inadequate follow-up
These mechanisms help explain why GLP-1s appear to trigger a significant 12% to 18% weight loss on average
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Si bien el metaanlisis logra demostrar los beneficios de estos frmacos habra que menciona algunas limitaciones: El uso de los datos agregados dificulta el anlisis por subgrupos
Mixing an approved drug with an investigational compound is the standard safety position
