For TB-500, the status is similar (Investigational New Drug in the US) with very limited human data
Similar to the protease discussed in the context of stroke, MS, and ALS, the cell-signaling analog of activate protein C, 3K3A-activated protein C, in addition to improving cerebrovascular integrity also diminished neuroinflammatory responses and slows the generation of amyloid-beta plaque buildup in AD model mice [129]
Blue light Has anti-inflammatory and antimicrobial properties, particularly relevant for chronic infections and biofilm-forming pathogens
Notch signaling pathway The Notch signaling pathway is activated by the binding of ligands to Notch receptors
This increase in cAMP may activate protein kinase A (PKA), which then appears to phosphorylate hormone-sensitive lipase (HSL) on specific serine sites
AMPK, a heterotrimeric kinase composed of catalytic and regulatory / subunits, is a master regulator of hepatic lipid metabolism 22