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In 2024, semaglutide was added to its anti-doping Monitoring Program
The SELECT trial, which supports the expanded indication, enrolled patients 45 years of age and older with pre-existing cardiovascular disease and a body-mass index of 27 or greater without diabetes
Because the compound lacks regulatory approval, any product marketed for human use is being sold through unofficial channels that do not meet pharmaceutical manufacturing standards, raising documented concerns about purity, composition, and contamination
31 In contrast, several small-molecule FXR agonists without a bile acid structural backbone may not worsen LDL cholesterol or cause pruritus, although this remains unproven
Similarly, a population-based study in Sweden found that individuals taking GLP-1 agonists for metabolic conditions had a lower incidence of alcohol-related disorders compared to matched controls
The adverse effects reported were consistent with whats already known about GLP-1 agonists
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