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Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation

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10.1093/jnci/91.7.620 J

Supplement timing, dosage, and safety decisions should be made in consultation with your prescribing physician, especially if you have pre-existing liver conditions or are taking medications that affect hepatic detoxification pathways