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No efficacy endpoint anchors it in humans

1012 Whereas, photo-aging (exposure to ultra-violet light) and chronologically aged skin are involved in a cascade of cellular and molecular signaling mechanisms (mainly due to oxidative stress)

However, under electrophilic or oxidative stress, KEAP1 changes its structure and NRF2 dissociates from the complex, accumulates in the nucleus and induces the expression of its target genes involved in the antioxidant response, detoxification, metabolism and inflammation [11]

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doi: 10.1152/physrev.00032.2020 3 PatniNGargA

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